These mutational fingerprints manifest as specific types of mutations e. Showcam Ngs Code Design UnveilsĪ pyrosequencing-tailored nucleotide barcode design unveils opportunities for large-scale sample multiplexing.įurthermore, we verify that the accuracy and reproducibility of this method are comparable with those of the currently available low-throughput method. Our study is the first demonstration of the applicability of these technologies for the detection of mutational fingerprint of carcinogens in a chromosomal gene in a validated mammalian model system 4 Such an approach is relatively costly, extensively time consuming and extremely laborious 4. The assay was performed using the commercially available Transpack Packaging Extract kit Stratagene according to the instructions of the manufacturer. The majority of these errors could be ascribed to false insertions and deletions.
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